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Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

Bibian M., Mangeschots J., Gardiner J., Waddington L., Acevedo M.M.D., De Geest B.G., Van Mele B., Madder A., Hoogenboom R. and Ballet S.Rational design of a hexapeptide hydrogelator for controlled-release drug delivery,Journal of Materials Chemistry B,3(5): 759,765,2015.

doi: 10.1039/c4tb01294a

The amphiphilic peptide sequence H-Phe-Glu-Phe-Gln-Phe-Lys-OH (MBG-1) is developed as a novel hydrogelator for use in controlled-drug release administration, which is the smallest tunable ionic self-complementary hydrogelating peptide reported to date making it attractive for larger scale preparation. Hydrogelation is demonstrated to result from self-assembly of the peptide into beta-sheet nanofibers that are physically cross-linked by intertwining as well as larger bundle formation. Finally, the release of two small molecule cargos, fluorescein sodium and ciprofloxacin hydrochloride, is demonstrated revealing a two-stage zero-order sustained release profile up to 80% cumulative release over eight days.

BibTeX

@article{,
    author  = "Bibian, M.; Mangeschots, J.; Gardiner, J.; Waddington, L.; Acevedo, M.M.D.; De Geest, B.G.; Van Mele, B.; Madder, A.; Hoogenboom, R.; Ballet, S.",
    title   = "Rational design of a hexapeptide hydrogelator for controlled-release drug delivery",
    journal = "Journal of Materials Chemistry B",
    year    = "2015",
    volume  = "3",
    number  = "5",
    pages   = "759,765",
    month   = "",
    doi     = "10.1039/c4tb01294a",
    note    = "",
}