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Asymmetric Synthesis

3 ECTS credits
78 h study time

Offer 1 with catalog number 4016085FNR for all students in the 2nd semester at a (F) Master - specialised level.

Information about this course is applicable on academic year 2017-2018.

2nd semester
Enrollment based on exam contract
Grading method

Grading (scale from 0 to 20)

Can retake in second session
Taught in
Partnership agreement
  • Under interuniversity agreement for degree program
Faculty of Science and Bio-engineering Sciences
Responsible organisation
Educational Team:
  • Guido VERNIEST (course titular)
    Activities and contact hours
    • 13 contact hours Lecture
    • 26 contact hours Independent or External Form of Study
    Course content

    This course focusses on advanced topics within the field of asymmetric chemistry. The following topics are discussed:

    1) General principles: stereochemical vocabulary, analytical methods, kinetic control and temperature effects.
    2) Asymmetric addition to carbonyl compounds (chiral auxiliaries, etc)

    3) The use of chiral enolates

    4) Asymmetric aldol reactions (Zimmerman-Traxler transition states, etc.)

    5) Asymmetric C=C bond transformations

    6) Asymmetric reductions and oxidations

    7) Stereochemical syntheses of alfa-aminoacids

    The part 'ZELF' includes the study of the asymmetric synthesis of amino acids 

    Course material
    • Course text (Required): Asymmetric Synthesis, copies of presented slides, Guido Verniest, VUBtiek, 2220170002330
    • Handbook (Recommended): Asymmetric synthesis, Aitken and Kilenyi, Blackie, 1992
    • Handbook (Recommended): Stereoselective synthesis, Atkinson, Wiley, 1995
    • Handbook (Recommended): Asymmetric synthesis, the essetnials, M. Christmann, Wiley, 2006
    Additional info

    This course is organized alternating yearly at VUB (Prof. Verniest) and at UGent (Prof. J. Van der Eycken).

    In the academic year 2017-2018, the course is organized by J. Van der Eycken at UGent.

    Programme Objectives

    Algemene competenties

    After following this course, the student:

    *is able to design a stereoselective synthesis.

    *has knowledge of the diversity of stereochemical synthesis and analysis methods in organic chemistry.



    The final grade is composed based on the following categories:

    • Oral Exam determines 100% of the final mark.

    Within the Oral Exam category, the following assignments need to be completed:

    exam oral with a relative weight of 1 which comprises 100% of the final mark.

    Note: Mondeling met schriftelijke voorbereiding. Eén examenvraag gaat over de theorie, een vraag over het bestudeerde wetenschappelijk artikel.

    Additional info with regard to grading

    Oral examination with written preparation.