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An international Collaborative Study of Intracytoplasmic Sperm Injection – Child and Family Outcomes (ICSI-CFO)

Friday, 24 October, 2008 - 17:00
Campus: Brussels Health Campus
Faculty: Medicine and Pharmacy
auditorium P. Brouwer
Alastair Sutcliffe
phd defence

This large international study was conducted over
a 30 month period and was jointly led by Dr
Alastair Sutcliffe (UCL) and Dr Maryse Bonduelle
(VUB).

ICSI-CFO arose due to an urgent need to
investigate the health of children born after ICSI
(invented at VUB) and conventional IVF (invented
in the UK). There were theoretical concerns about
the safety of ICSI. Methods; 1550 children were
studied in 5 European countries (1/3 in UK, 1/3 in
Belgium and the other 1/3 in Sweden, Denmark
and Greece). These children were aged 5 years
and consisted of approximately equal groups of
ICSI conceived; IVF conceived and naturally
conceived (NC) children. After training in London,
paediatric/child psychologists pairs applied the
extensive protocol of checks which included full
neurodevelopmental scoring, laterality testing,
congenital anomalies and other physical checks
and finally assessment of general health, and
tests of family relations. Findings; these ICSI
conceived children born after 32 weeks gestation
were found to be similar in most aspects of
health to IVF comparison group and NC control
group. There were more congenital anomalies
and a higher tendency to access health service
resources. However psychometric, laterality,
neuromotor and general health checks were all
normal. Conclusions; within the limitations of this
large study, initially we can be confident that
health of ICSI singleton mature children in
Europe is generally satisfactory.