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Study of Vessel Mediated Physiological Parameters by Perfusion Magnetic Resonance Imaging

Wednesday, 16 April, 2008 - 17:00
Campus: Brussels Health Campus
Faculty: Medicine and Pharmacy
auditorium 3
Smitha Makkat
phd defence

This study investigates the use of vessel
mediated physiological parameters derived from
perfusion Magnetic Resonance (MR) imaging to
better understand breast pathology and enable
more accurate clinical decision making. The
acquisition/post processing strategies of
deconvolution based perfusion MR imaging
applied to breast pathology were explored. It was
demonstrated that the deconvolution of relative
enhancement data based on Turbo Field Echo
images acquired after a second bolus injection of
Gadolinium chelate (added to a routine breast MR
imaging protocol) enables the quantification of
perfusion parameters in human breast tumors.
Tumor Blood Flow (TBF), Tumor Volume of
Distribution (TVD) and Mean Transit Time (MTT)
were derived and compared with the classic (age,
size, grade and lymph node status) as well as
molecular (hormone receptor (HR) status, HER-2
protein and gene status) prognostic markers. It
was shown that the high TBF found in poor
prognostic cases (HER-2 positive and HR
negative groups) is an early and physiologically
specific indicator of the biological activity. Thus,
TBF and its pattern may deliver supporting
prognostic information for breast tumors in a
non-invasive manner. The mean TBF values from
these initial studies were higher than the results
from Positron Emission Tomography (PET)
studies. The potential causes for this
overestimation were further explored and a
modification of the method (addition of a
prebolus) to overcome these issues was proposed
and successfully implemented in a small cohort of
patients. The resulting TBF values were shown to
fall well within the PET literature data range.