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Epidemiology, Diagnosis, and Treatment of Gastro-esophageal Reflux, focusing on Indonesian Infants

Wednesday, 27 April, 2011 - 15:00
Campus: Brussels Health Campus
Faculty: Medicine and Pharmacy
auditorium P. Brouwer
Badriul Hegar Syarif
phd defence

The topic of this thesis focuses on clinical aspects
of physiologic gastro-esophageal reflux and reflux
disease, and can be divided in two major parts.
One part focuses on GER-research. We provide
an overview of "general knowledge" on GER(D)
management when this work started (end 199ies,
early years 2000). Different aspects of the impact
of esophageal pH monitoring are discussed,
regarding acceptability and technical aspects of
esophageal pH monitoring. Although thickened
commercialized formula decreases regurgitation,
the difference with cereal-thickened formula or
even natural evolution is limited. The efficacy of
domperidone and cisapride on infant
regurgitation is similar; cisapride seems more
effective regarding reflux according to pH
monitoring results.

The other part focuses on the local Indonesian
situation. The impact of regurgitation in
Indonesian families does not differ substantially
from publications in the developed world.

The perception of regurgitation and the actions
taken by parents differs between populations and
countries. We collected data on the prevalence
and natural evolution of regurgitation in
Indonesian infants. However, Indonesian health
care providers need a better understanding of the
symptoms, diagnosis and management of infant
regurgitation, GER and GERD. The candidate has
already started this project in collaboration with
the Indonesian Society of Pediatrics.