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Health of ICSI children

Thursday, 31 May, 2012 - 17:00
Campus: Brussels Health Campus
Faculty: Medicine and Pharmacy
auditorium P. Brouwer
Florence Belva
phd defence

Intracytoplasmic Sperm Injection (ICSI) involves
the injection of one spermatozoon directly into an
oocyt. This technique was developed 20 years
ago at the UZ Brussel for the alleviation of
infertility due to severe semen abnormalities.
Although, today, more than 2.5 million children
are born after ICSI worldwide, safety concerns
for the offspring remain since a number of steps
occurring in natural conception are being
bypassed. The research topic of this thesis is the
medical health outcome of pre-pubertal and
pubertal children conceived by ICSI in
comparison with peers born after spontaneous
conception. The study at the age of 8 years was
one of the first to investigate overall health and
trends in morbidity in ICSI and therefore a broad
scale of developmental aspects were studied. Due
to the important finding of higher blood pressure
in 8-year-old ICSI offspring, a follow-up study
was set up at the age of 14 years in order to
evaluate cardiometabolic disease risk following
ICSI. In view of this, adiposity risk and blood
pressure measurements were assessed. Since
ICSI children and their peers proceeded into
puberty, sexual maturation and early detectable
infertility markers were additionally assessed in
the worldwide eldest ICSI cohort followed since

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